Quantitation of anticonvulsant drugs in serum by gas-chromatography on the stationary phase SP-2510.
نویسندگان
چکیده
A new column packing, SP-2510 DA (Supelco, Inc., Bellefonte, Pa. 16823), is an excellent stationary phase for the determination of a wide variety of anticonvulsant drugs by gas--liquid chromatography without derivatization. However, when uncomplicated extraction procedures are used, serum cholesterol interferes with the determination of primidone. By the simple expedient of adding a short "pre-column" containing another phase (SP-2250 DA) the problem is overcome.
منابع مشابه
Unnecessary urinary electrolyte measurements.
1. Godolphin, W., and Thoma, J., Quantitation of anticonvulsant drugs in serum by gas-liquid chromatography on the stationary phase SP-2510. C/in. Chem. 24, 483 (1978). 2. Hewitt, T. E., Sievers, D. Z., and Kessler, 0., Improved gas-chromatographic analysis for anticonvulsants. C/in. (‘hero. 24, 1854 (1978). 3. Bredesen, J. E., and .Johannesen, S. I., Simultaneous determination of some antiepil...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1978